Fish Models in Impact Assessment of Carcinogenic Potential of Environmental Chemical Pollutants: An Appraisal of Hermaphroditic Mangrove Killifish Kryptolebias marmoratus
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چکیده
Fish models have gained acceptability in toxicological research in a big way. The major stimulus comes from two much-researched fish, medaka (Oryzias latipes) and zebrafish (Danio rerio). To a lesser extent, rainbow trout (Oncorhynchus mykiss) also pioneered research mostly on the liver cancer development and prevention. Recent understanding of genomes of these fish and finding of extensive homology between fish and human genomes have further catapulted their position in toxicology research and search for mechanisms and remedies for human diseases. Induction of cancer in most of the fish is rapid requiring low dose and short duration of exposure. About 20 years back it was demonstrated in Kryptolebias marmoratus that a single low dose exposure to carcinogen rapidly induced tumors. K. marmoratus is the only known internally self-fertilizing vertebrate. It has shown high sensitivity to a number of carcinogens. Furthermore, recent studies have demonstrated that exposure to endocrine-disrupting chemicals (EDCs) modulated expression of genes critical in tumor development and regulation. For example, exposure to EDCs caused significant increase in p53 expression within 3 h in juveniles. Similarly, some EDCs also modulated expression of Ras oncogenes. It is suggested that K. marmoratus can be used in study of environmental carcinogenesis and impact assessment of EDCs and environmental carcinogens.
منابع مشابه
Population genetics and evolution of the mangrove rivulus Kryptolebias marmoratus, the world's only self-fertilizing hermaphroditic vertebrate.
The mangrove rivulus, Kryptolebias marmoratus (Rivulidae, Cyprinodontiformes), is phylogenetically embedded within a large clade of oviparous (egg laying) and otherwise mostly gonochoristic (separate sex) killifish species in the circumtropical suborder Aplocheiloidei. It is unique in its reproductive mode: K. marmoratus is essentially the world's only vertebrate species known to engage routine...
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The hermaphroditic Mangrove Killifish, Kryptolebias marmoratus, is the world's only vertebrate that routinely self-fertilizes. As such, highly inbred and presumably isogenic "clonal" lineages of this androdioecious species have long been maintained in several laboratories and used in a wide variety of experiments that require genetically uniform vertebrate specimens. Here we conduct a genetic i...
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تاریخ انتشار 2009